Knoblich J A
Research Institute of Molecular Pathology, Vienna, Austria.
Curr Opin Cell Biol. 1997 Dec;9(6):833-41. doi: 10.1016/s0955-0674(97)80085-3.
Recent years have seen the discovery of machineries for asymmetric cell division in a number of different organisms. The Inscuteable protein is a central component of such a machinery in Drosophila. Within dividing Drosophila neural precursor cells, Inscuteable directs both the orientation of the mitotic spindle and the asymmetric segregation of the proteins Numb, Prospero and Miranda into one of the two daughter cells. Numb can act by repressing signalling via the transmembrane receptor Notch, whereas Miranda localizes the transcription factor Prospero which initiates daughter cell specific gene expression. The identification of Numb homologs in other species has suggested that this machinery might be conserved from Drosophila to vertebrates.
近年来，在许多不同的生物体中发现了用于不对称细胞分裂的机制。Inscuteable蛋白是果蝇中这种机制的核心组成部分。在分裂的果蝇神经前体细胞中，Inscuteable指导有丝分裂纺锤体的方向以及蛋白质Numb、Prospero和Miranda不对称地分离到两个子细胞之一中。Numb可以通过抑制跨膜受体Notch的信号传导来发挥作用，而Miranda则定位转录因子Prospero，后者启动子细胞特异性基因表达。在其他物种中鉴定出Numb同源物表明，这种机制可能从果蝇到脊椎动物都是保守的。
