伊斯帕尼奥拉岛脊髓灰质炎疫情与1型循环疫苗衍生脊髓灰质炎病毒有关。

Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus.

作者信息

Kew Olen, Morris-Glasgow Victoria, Landaverde Mauricio, Burns Cara, Shaw Jing, Garib Zacarías, André Jean, Blackman Elizabeth, Freeman C Jason, Jorba Jaume, Sutter Roland, Tambini Gina, Venczel Linda, Pedreira Cristina, Laender Fernando, Shimizu Hiroyuki, Yoneyama Tetsuo, Miyamura Tatsuo, van Der Avoort Harrie, Oberste M Steven, Kilpatrick David, Cochi Stephen, Pallansch Mark, de Quadros Ciro

机构信息

Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA.

出版信息

Science. 2002 Apr 12;296(5566):356-9. doi: 10.1126/science.1068284. Epub 2002 Mar 14.

DOI:10.1126/science.1068284

PMID:11896235

Abstract

An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000-2001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998-1999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.

摘要

2000 - 2001年期间，多米尼加共和国（13例确诊病例）和海地（8例确诊病例，包括2例死亡病例）发生了麻痹性脊髓灰质炎疫情。除1名患者外，其余患者均为未接种疫苗或未完全接种疫苗的儿童，且病例发生在口服脊髓灰质炎疫苗（OPV）覆盖率极低（7%至40%）的社区。此次疫情与1型OPV毒株的一个衍生毒株的传播有关，该衍生毒株可能源自1998 - 1999年接种的一剂OPV。与此次疫情相关的疫苗衍生脊髓灰质炎病毒的生物学特性与野生脊髓灰质炎病毒无法区分。