Mirmirani Paradi, Maurer Toby A, Berger Timothy G, Sands Laura P, Chren Mary-Margaret
Department of Dermatology, University of California, San Francisco, California 94143-0316, USA.
J Cutan Med Surg. 2002 Jan-Feb;6(1):10-5. doi: 10.1007/s10227-001-0033-x. Epub 2002 Jan 9.
The overall health status and survival of HIV-infected patients has changed with the advent of highly active antiretroviral therapy (HAART). With this improved survival, there is a greater urgency to study quality-of-life issues.
Our objectives were to measure skin-related quality of life in a cohort of HIV-infected patients and to determine whether the use of highly active antiretroviral therapy is associated with improved skin-related quality of life.
We assembled a retrospective cohort of patients who were seen in our HIV-Dermatology Clinic at San Francisco General Hospital in June, July, or August of 1996. Eligible subjects were contacted by mail and asked (1) to complete a questionnaire (Skindex) and (2) to have a skin exam. Information on medication use and laboratory parameters was also collected.
Of 107 eligible patients, 76 (71%) responded to the questionnaire; 60 patients were examined. Many patients had multiple skin conditions. For most diagnoses (except warts and onychomycosis), there were no consistent differences in Skindex scores of HIV-infected patients compared with scores of patients not known to be infected with HIV. Patients on HAART for longer duration had significantly lower Skindex scores (improved skin-related quality of life) compared with those on HAART for a shorter duration.
HAART is associated with improved quality of life with regard to HIV-associated skin diseases.
随着高效抗逆转录病毒疗法（HAART）的出现，HIV感染患者的总体健康状况和生存率发生了变化。随着生存率的提高，研究生活质量问题变得更加紧迫。
我们的目标是测量一组HIV感染患者与皮肤相关的生活质量，并确定使用高效抗逆转录病毒疗法是否与改善皮肤相关的生活质量相关。
我们收集了1996年6月、7月或8月在旧金山综合医院的HIV皮肤科门诊就诊的患者的回顾性队列。通过邮件联系符合条件的受试者，要求他们（1）完成一份问卷（Skindex），（2）进行皮肤检查。还收集了用药信息和实验室参数。
在107名符合条件的患者中，76名（71%）回复了问卷；对60名患者进行了检查。许多患者有多种皮肤疾病。对于大多数诊断（除了疣和甲癣），与未感染HIV的患者相比，HIV感染患者的Skindex评分没有一致的差异。与接受HAART治疗时间较短的患者相比，接受HAART治疗时间较长的患者Skindex评分显著较低（皮肤相关生活质量改善）。
HAART与改善HIV相关皮肤疾病的生活质量相关。
