血管活性肠肽与SIN-1对人离体海绵体动脉和海绵体的非协同舒张作用

Non-synergistic relaxant effects of vasoactive intestinal polypeptide and SIN-1 in human isolated cavernous artery and corpus cavernosum.

作者信息

Hempelmann R G, Papadopoulos I, Herzig S

机构信息

Department of Pharmacology, University of Kiel, Germany.

出版信息

Eur J Pharmacol. 1995 Apr 4;276(3):277-80. doi: 10.1016/0014-2999(95)00081-u.

DOI:10.1016/0014-2999(95)00081-u

PMID:7601214

Abstract

Since vasoactive intestinal peptide (VIP) and nitric oxide (NO) are considered to be non-adrenergic, non-cholinergic (NANC) inhibitory mediators in human penile erectile tissue, the goal of this study was to discover possible synergistic effects of exogeneous VIP and the NO donor 3-morpholino-sydnonimine (SIN-1) in human isolated cavernous arteries and cavernosal smooth muscle. In contrast to VIP, SIN-1 elicited complete and reproducible relaxant actions. Combined administration of VIP and SIN-1 revealed non-synergistic, independent relaxant effects in both investigated tissues. The results do not favour a combined administration of VIP and SIN-1 as a new therapeutic approach in the treatment of erectile dysfunction.

摘要

由于血管活性肠肽（VIP）和一氧化氮（NO）被认为是人类阴茎勃起组织中的非肾上腺素能、非胆碱能（NANC）抑制介质，本研究的目的是发现外源性VIP与NO供体3-吗啉代西多胺（SIN-1）在人离体海绵体动脉和海绵体平滑肌中可能的协同作用。与VIP不同，SIN-1可引发完全且可重复的舒张作用。VIP和SIN-1联合给药在两种被研究组织中均显示出非协同、独立的舒张作用。这些结果不支持将VIP和SIN-1联合给药作为治疗勃起功能障碍的一种新的治疗方法。