Kunitomi M, Wada J, Takahashi K, Tsuchiyama Y, Mimura Y, Hida K, Miyatake N, Fujii M, Kira S, Shikata K, Maknio H
Department of Medicine III, Okayama University Medical School, Okayama, Japan.
Int J Obes Relat Metab Disord. 2002 Mar;26(3):361-9. doi: 10.1038/sj.ijo.0801899.
To investigate whether the changes in IGF-I concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat.
Cross-sectional and longitudinal clinical intervention study with exercise education.
One-hundred and twelve Japanese overweight men aged 30-59 y (body mass index (BMI) 28.4+/-2.5 kg/m(2)) and 33 normal-weight men aged 30-39 y (BMI 22.1+/-1.5 kg/m(2)) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8+/-2.8) were further enrolled into a 1 y exercise program.
Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-I at baseline and after 1 y.
In 112 overweight subjects at baseline, insulin (10.5+/-5.0 microU/ml) and leptin (6.4+/-3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-I (156.8+/-48.7 microU/ml) significantly and negatively correlated with V area (r=-0.242, P=0.0125) and age (r=-0.192, P=0.0480). In normal-weight men aged 30-39 y (n=33) and age-matched subjects (n=30) selected from the 112 overweight men, the serum IGF-I further tightly correlated with V area (r=-0.467, P<0.0001). Visceral fat area and age were independently related to serum IGF-I levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224+/-2781 to 7898+/-4141 steps/day) and reduction of BMI (28.8+/-2.8 to 27.7+/-2.9). deltaIGF-I significantly correlated with deltaV area (r=-0.432, P=0.0009) but not with DeltaS area or deltaBMI.
The present study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention.
研究日本超重男性减重后胰岛素样生长因子-Ⅰ（IGF-Ⅰ）浓度的变化是否与内脏脂肪和皮下脂肪的变化相关。
采用运动教育的横断面和纵向临床干预研究。
112名年龄在30 - 59岁的日本超重男性（体重指数（BMI）28.4±2.5kg/m²）和33名年龄在30 - 39岁的正常体重男性（BMI 22.1±1.5kg/m²）作为基线研究对象。从参与者中，随机选取56名超重男性（BMI 28.8±2.8）进一步纳入为期1年的运动计划。
通过脐水平计算机断层扫描测量内脏脂肪（V）和皮下脂肪（S）面积来评估脂肪分布，在基线和1年后测量代谢参数以及包括胰岛素、瘦素和IGF-Ⅰ在内的激素。
在112名超重受试者基线时，胰岛素（10.5±5.0微单位/毫升）和瘦素（6.4±3.7纳克/毫升）分别与V面积（r = 0.260，P = 0.0073；r = 0.410，P < 0.0001）和S面积（r = 0.377，P < 0.0001；r = 0.613，P < 0.0001）显著相关。IGF-Ⅰ（156.8±48.7微单位/毫升）与V面积（r = -0.242，P = 0.0125）和年龄（r = -0.192，P = 0.0480）显著负相关。在30 - 39岁的正常体重男性（n = 33）和从112名超重男性中选取的年龄匹配受试者（n = 30）中，血清IGF-Ⅰ与V面积进一步密切相关（r = -0.467，P < 0.0001）。通过多元回归分析，内脏脂肪面积和年龄与血清IGF-Ⅰ水平独立相关。通过运动教育干预，56名超重受试者每日步数增加（从6224±2781步/天增加到7898±4141步/天）且BMI降低（从28.8±2.8降至27.7±2.9）。ΔIGF-Ⅰ与ΔV面积显著相关（r = -0.432，P = 0.0009），但与ΔS面积或ΔBMI无关。
本研究表明基线时IGF-Ⅰ水平与内脏脂肪呈负相关，以及运动干预后内脏脂肪减少与IGF-Ⅰ水平升高之间存在关联。
