Miyatake Nobuyuki, Takahashi Kayo, Wada Jun, Nishikawa Hidetaka, Morishita Akie, Suzuki Hisao, Kunitomi Mie, Makino Hirofumi, Kira Shohei, Fujii Masafumi
Okayama Southern Institute of Health, 408-1 Hirata, Okayama 700-0952, Japan.
Diabetes Res Clin Pract. 2003 Dec;62(3):149-57. doi: 10.1016/s0168-8227(03)00176-1.
To investigate the link between a reduction in blood pressure (BP) and daily exercise.
Cross-sectional and longitudinal clinical intervention study with exercise education.
43 overweight Japanese men aged 32-59 years (BMI, 29.0+/-2.3 kg/m2) at baseline. Among the participants, a randomly selected 23 overweight men (BMI, 28.5+/-1.7) were further enrolled into the 10 months exercise program.
BP was measured every week and steps per day were also recorded every day throughout the observation period. Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography (CT) scanning at umbilical level, at before, 5 months and after intervention. Anthropometric parameters were also measured at same point. Aerobic exercise level, muscle strength, flexibility and calorie intake and insulin resistance (HOMA index) were investigated at before and after the study.
In a cross sectional analysis, systolic BP (SBP) and diastolic BP (DBP) were significantly correlated with body composition. In a second longitudinal analysis, SBP was significantly reduced at 2 months and DBP was also reduced at 3 months, and almost maintained until the end of the observation period. Increasing daily walking was observed in 3 months and maintained until 10 months. Body composition, aerobic exercise level, muscle strength, flexibility and insulin resistance were significantly improved. There was positive correlation between DeltaDBP and Deltavisceral fat area (1-5, 5-10, 1-10 months). By stepwise multiple regression analysis, only Deltavisceral fat area was independently related to DeltaDBP at a significant level (1-10 months: DeltaDBP=-0.608+0.105Deltavisceral fat area, r2=0.227, P=0.0334).
The present study indicated daily exercise lowers BP and visceral fat area is the critical factor for BP change.
研究血压降低与日常锻炼之间的联系。
采用运动教育的横断面和纵向临床干预研究。
43名基线时年龄在32 - 59岁之间的超重日本男性（BMI，29.0±2.3 kg/m²）。在参与者中，随机选取23名超重男性（BMI，28.5±1.7）进一步纳入为期10个月的运动计划。
在整个观察期内，每周测量血压，每天记录每日步数。通过在脐水平进行计算机断层扫描（CT）测量内脏脂肪（V）和皮下脂肪（S）面积来评估脂肪分布，分别在干预前、干预5个月和干预后进行测量。在相同时间点还测量人体测量参数。在研究前后调查有氧运动水平、肌肉力量、柔韧性以及卡路里摄入量和胰岛素抵抗（HOMA指数）。
在横断面分析中，收缩压（SBP）和舒张压（DBP）与身体组成显著相关。在第二项纵向分析中，SBP在2个月时显著降低，DBP在3个月时也降低，并且几乎维持到观察期结束。在3个月时观察到每日步行量增加，并维持到10个月。身体组成、有氧运动水平、肌肉力量、柔韧性和胰岛素抵抗均得到显著改善。DeltaDBP与内脏脂肪面积变化（1 - 5个月、5 - 10个月、1 - 10个月）之间存在正相关。通过逐步多元回归分析，仅内脏脂肪面积变化在显著水平上与DeltaDBP独立相关（1 - 10个月：DeltaDBP = -0.608 + 0.105内脏脂肪面积变化，r² = 0.227，P = 0.0334）。
本研究表明日常锻炼可降低血压，且内脏脂肪面积是血压变化的关键因素。
