Suleiman H M, Aliyu I S, Abubakar S A, Isa M S, El-Bashir J M, Adamu R, Ibrahim M Z, Mohammed A, Yusuf R, Manu M, Dogara A B, Mustapha S K, Bello N, Ozovehe S A
Department of Chemical Pathology, Ahmadu Bello University, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Department of Medicine, Ahmadu Bello University, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Niger J Clin Pract. 2017 Dec;20(12):1618-1621. doi: 10.4103/njcp.njcp_78_17.
Stroke has been a global burden, with increasing morbidity and mortality. Serum cardiac troponin t (cTnT) and creatine kinase (CK-MB) fraction are reported to be elevated in patients admitted with acute ischaemic stroke and high level of these biomarkers indicated more severe stroke and neurologic deficit in some of the patients.
To evaluate the serum levels cardiac troponin t (cTnT) and creatine kinase MB fraction (CK-MB) in patients with acute ischaemic stroke and relate the analytes to severity of stroke.
Patients with clinical diagnosis of ischaemic stroke diagnosed, confirmed by brain Computerized Tomography scan and equal number of apparently healthy age and sex-matched were recruited. Serum cardiac troponin t (cTnT) and creatine kinase MB fraction (CK-MB) were analysed using ELISA method and Stroke severity was determined using National Institute of Health Stroke Score (NIHSS).
Mean serum cardiac troponin t (cTnT) and creatine kinase MB fraction (CK-MB) in stroke patients were found to be higher than age sex matched control (p<0.05). NIHS Score of 12.2 ± 5.43 and 9.78 ± 3.97 were observed in Patients with elevated and normal cTnT respectively (p=0.009) while NIHS Score were similar in patients with elevated and normal CK-MB (p = 0.772).
The mean values of serum cTnT and CK-MB were higher in acute ischaemic stroke patients compared to controls. Serum cardiac Troponin t level may be a significant biomarker of the severity of stroke.
中风一直是一项全球性负担，其发病率和死亡率不断上升。据报道，急性缺血性中风患者的血清心肌肌钙蛋白T（cTnT）和肌酸激酶（CK-MB）同工酶水平会升高，并且这些生物标志物的高水平表明部分患者的中风和神经功能缺损更为严重。
评估急性缺血性中风患者的血清心肌肌钙蛋白T（cTnT）和肌酸激酶MB同工酶（CK-MB）水平，并将这些分析物与中风严重程度相关联。
招募经脑部计算机断层扫描确诊为缺血性中风的患者以及数量相等、年龄和性别匹配的明显健康对照者。采用酶联免疫吸附测定法分析血清心肌肌钙蛋白T（cTnT）和肌酸激酶MB同工酶（CK-MB），并使用美国国立卫生研究院卒中量表（NIHSS）确定中风严重程度。
发现中风患者的血清心肌肌钙蛋白T（cTnT）和肌酸激酶MB同工酶（CK-MB）的平均水平高于年龄和性别匹配的对照组（p<0.05）。cTnT升高和正常的患者的NIHSS评分分别为12.2±5.43和9.78±3.97（p=0.009），而CK-MB升高和正常的患者的NIHSS评分相似（p = 0.772）。
与对照组相比，急性缺血性中风患者血清cTnT和CK-MB的平均值更高。血清心肌肌钙蛋白T水平可能是中风严重程度的一项重要生物标志物。
