丝孢酵母属菌种的体外抗真菌药敏性
In vitro antifungal susceptibilities of Trichosporon species.
作者信息
Paphitou Niki I, Ostrosky-Zeichner Luis, Paetznick Victor L, Rodriguez Jose R, Chen Enuo, Rex John H
机构信息
Laboratory for Mycology Research, Center for the Study of Emerging and Re-Emerging Pathogens, Division of Infectious Diseases, University of Texas-Houston Medical School, Houston, Texas 77030, USA.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1144-6. doi: 10.1128/AAC.46.4.1144-1146.2002.
Abstract
The in vitro activities of amphotericin B, itraconazole, fluconazole, voriconazole, posaconazole, and ravuconazole against 39 isolates of Trichosporon spp. were determined by the NCCLS M27-A microdilution method. The azoles tested appeared to be more potent than amphotericin B. Low minimal fungicidal concentration/MIC ratios were observed for voriconazole, posaconazole, and ravuconazole, suggesting fungicidal activity.
摘要
采用美国国立临床实验室标准化委员会（NCCLS）M27 - A微量稀释法测定了两性霉素B、伊曲康唑、氟康唑、伏立康唑、泊沙康唑和拉夫康唑对39株毛孢子菌属菌株的体外抗菌活性。所测试的唑类药物似乎比两性霉素B更有效。观察到伏立康唑、泊沙康唑和拉夫康唑的最低杀菌浓度/最低抑菌浓度比值较低，提示有杀菌活性。
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