efg1/efg1 cph1/cph1双缺失突变体（一种丝状生长有缺陷的白色念珠菌菌株）不会发生导管感染。
Lack of catheter infection by the efg1/efg1 cph1/cph1 double-null mutant, a Candida albicans strain that is defective in filamentous growth.
作者信息
Lewis Russell E, Lo Hsiu-Jung, Raad Issam I, Kontoyiannis Dimitrios P
机构信息
Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1153-5. doi: 10.1128/AAC.46.4.1153-1155.2002.
Abstract
The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.
摘要
目前尚不清楚调节白色念珠菌在异物上成功定殖的分子调控机制。在此我们表明，一株丝状生长缺陷且缺乏转录因子Efg1p和Cph1p的白色念珠菌突变株，在聚氨酯导管上定殖的潜力严重不足。
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本文引用的文献
1
Signal transduction cascades regulating fungal development and virulence.调节真菌发育和毒力的信号转导级联反应。
Microbiol Mol Biol Rev. 2000 Dec;64(4):746-85. doi: 10.1128/MMBR.64.4.746-785.2000.
2
Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture.由在培养中丝状生长存在缺陷的白色念珠菌突变体产生的含有丝状形态的侵袭性病变。
Infect Immun. 1999 Jul;67(7):3649-52. doi: 10.1128/IAI.67.7.3649-3652.1999.
3
Nonfilamentous C. albicans mutants are avirulent.非丝状白色念珠菌突变体无致病性。
Cell. 1997 Sep 5;90(5):939-49. doi: 10.1016/s0092-8674(00)80358-x.
4
Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi.Efg1p是人类病原体白色念珠菌形态发生的关键调节因子，属于一类保守的bHLH蛋白，这类蛋白在真菌中调节形态发生过程。
EMBO J. 1997 Apr 15;16(8):1982-91. doi: 10.1093/emboj/16.8.1982.
5
Nosocomial candidiasis: emerging species, reservoirs, and modes of transmission.医院念珠菌病：新出现的菌种、储存宿主及传播方式。
Clin Infect Dis. 1996 May;22 Suppl 2:S89-94. doi: 10.1093/clinids/22.supplement_2.s89.
6
Isogenic strain construction and gene mapping in Candida albicans.白色念珠菌的同基因菌株构建与基因定位
Genetics. 1993 Jul;134(3):717-28. doi: 10.1093/genetics/134.3.717.
7
Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog.通过STE12同源物突变抑制白色念珠菌的菌丝形成。
Science. 1994 Dec 9;266(5191):1723-6. doi: 10.1126/science.7992058.
8
Adherence of candida species to intravenous catheters.念珠菌属对静脉内导管的黏附
J Infect Dis. 1983 Mar;147(3):594. doi: 10.1093/infdis/147.3.594.
9
Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory.临床微生物实验室中超声处理血管导管培养物的三年经验。
J Clin Microbiol. 1990 Jan;28(1):76-82. doi: 10.1128/jcm.28.1.76-82.1990.
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