Lewis Russell E, Lo Hsiu-Jung, Raad Issam I, Kontoyiannis Dimitrios P
Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Antimicrob Agents Chemother. 2002 Apr;46(4):1153-5. doi: 10.1128/AAC.46.4.1153-1155.2002.
The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.
目前尚不清楚调节白色念珠菌在异物上成功定殖的分子调控机制。在此我们表明,一株丝状生长缺陷且缺乏转录因子Efg1p和Cph1p的白色念珠菌突变株,在聚氨酯导管上定殖的潜力严重不足。