白色念珠菌中厚垣孢子的形成需要Efg1p形态发生调节因子。
Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator.
作者信息
Sonneborn A, Bockmühl D P, Ernst J F
机构信息
Institut für Mikrobiologie, Heinrich-Heine-Universität, D-40225 Düsseldorf, Germany.
出版信息
Infect Immun. 1999 Oct;67(10):5514-7. doi: 10.1128/IAI.67.10.5514-5517.1999.
Abstract
Chlamydospore formation of the fungal pathogen Candida albicans was found to depend on the Efg1 protein, which regulates the yeast-hyphal transition. Isogenic mutants lacking EFG1 or encoding T206A and T206E variants did not differentiate chlamydospores, while cek1, cph1, or tpk2 mutations had no effect. Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions suggests a novel Efg1p/Cph1p-independent filamentation pathway in C. albicans.
摘要
已发现真菌病原体白色念珠菌的厚垣孢子形成依赖于Efg1蛋白，该蛋白调节酵母-菌丝转变。缺乏EFG1或编码T206A和T206E变体的同基因突变体不能分化出厚垣孢子，而cek1、cph1或tpk2突变则没有影响。此外，efg1 cph1双突变体在微需氧条件下的丝状化表明白色念珠菌中存在一条新的不依赖Efg1p/Cph1p的丝状化途径。
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