Malkov J J
Zentralbl Gynakol. 1975;97(17):1047-56.
Properdin-titers of 1350 women were determined to appreciate the properdin-system in obstetrics and gynaecology. At first the means of properdin of healthy pregnant women (separated to three months-terms) and blood donors were determined. Then the quantities of properdin-system of pregnant women, parturients and lying-in women with pathologic processes and extragenital diseases and of patients with gynaecologic diseases were explored. The properdin-titer of healthy women at the end of gestation was increased. With a level of 99,6 units the central properdin-titer of these women was lower than the central titer of female blood donors with a level of 109,6 units. During delivery the properdintiter of healthy women decreased, in the period after childbirth it increased again. The determination of properdin of pregnant women, parturients and lying-in women with rheumatic heart defects and gestosises is of great importance. The properdin-titer was low in cases with severe heart diseases and a long issue. The prognostic significance of the test demonstrates the good event of pregnancies, deliveries, post partum periods and late gestosises of women with high properdin-titer regardless of the severity of the pathological state. In comparison with the titer of healthy lying-in women attention is to be directed to the slow rising of the properdin-titer of lying-in women after complicated pregnancy. In cases of gynaecological diseases the determination of the properdin-titer has three purposes: The control of the severity of the disease, the control of the effectiveness of the therapy and the evidence of the prognosis. This is especially conclusive for inflammatory diseases of the genital organs. The worse the turn of the inflammatory disease, the more was the decrease of the properdin-titer and the slower was the activation of the properdin-system in the organism. In cases of septic diseases the importance of the properdin level for prognostic assertion must also be pointed out. The remaining low properdin-titer and its further decrease is characteristical for most of these patients, who show in spite of modern therapeutical methods a long turn of the disease, new septic metastases and a considerable reduction of the general state of health.
检测了1350名女性的备解素滴度，以评估妇产科领域的备解素系统。首先测定了健康孕妇（按孕期三个月分组）和献血者的备解素均值。然后研究了患有病理过程和生殖器外疾病的孕妇、产妇和产褥期妇女以及患有妇科疾病患者的备解素系统量。妊娠末期健康女性的备解素滴度升高。这些女性的中心备解素滴度为99.6单位，低于女性献血者的中心滴度109.6单位。分娩期间健康女性的备解素滴度下降，产后又再次升高。测定患有风湿性心脏缺陷和妊娠中毒症的孕妇、产妇和产褥期妇女的备解素具有重要意义。患有严重心脏病且病程较长的病例中备解素滴度较低。该检测的预后意义表明，无论病理状态的严重程度如何，备解素滴度高的女性在妊娠、分娩、产后时期和晚期妊娠中毒症方面的情况良好。与健康产褥期女性的滴度相比，应注意复杂妊娠后产褥期女性备解素滴度上升缓慢的情况。在妇科疾病病例中，测定备解素滴度有三个目的：控制疾病的严重程度、控制治疗效果和判断预后。这在生殖器器官炎症性疾病中尤为明显。炎症性疾病的病情越差，备解素滴度下降越多，机体中备解素系统的激活就越慢。在败血症病例中，也必须指出备解素水平对预后判断的重要性。这些患者中的大多数其备解素滴度持续较低且进一步下降，尽管采用了现代治疗方法，疾病病程仍较长，出现新的败血症转移，且整体健康状况大幅下降。
