[Dependence of the contractility of the non-pregnant human uterus from the perfusion pressure of the vascular bed during the menstrual cycle].

The relation between the contractile activity of the isolated non-pregnant human uterus and the perfusion pressure of its vascular bed has been investigated. Experiments have been carried out on 35 isolated human uteri obtained at operations from various phases of the cycle. It has been found that the contractile activity of the non-pregnant human uterus is characterised by the lack of contraction coordination in the course of the sexual cycle with particular attention to this property in the midcycle. Regularly coordinated contractions have been recorded in the period of menstrual bleeding only. Moreover, it has been demonstrated that there is a close relation between the quality of the contractile activity and perfusion pressure in the vascular bed of the isolated human uterus, i.e. contractions with a small amplitude (4 to 8 mmHg) have as a rule no influence on the perfusion pressure whereas contractions with a higher amplitude (over 15 mHg) influence very distinctly the perfusion pressure in the vascular bed of the isolated human uterus. Obtained results have been discussed with reference to the physiology of the contractile activity basic processes of the nonpregnant human uterus.