运动期间血浆腺苷浓度升高：哮喘运动诱发支气管收缩的一个可能促成因素。

Plasma adenosine concentration increases during exercise: a possible contributing factor in exercise-induced bronchoconstriction in asthma.

作者信息

Vizi Eva, Huszár Eva, Csoma Zsuzsa, Böszörményi-Nagy György, Barát Erzsébet, Horváth Ildikó, Herjavecz Irén, Kollai Márk

机构信息

Department of Pathophysiology, National Korányi Institute for Tuberculosis and Pulmonology, Budapest, Hungary.

出版信息

J Allergy Clin Immunol. 2002 Mar;109(3):446-8. doi: 10.1067/mai.2002.121955.

DOI:10.1067/mai.2002.121955

PMID:11897989

Abstract

We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 +/- 35 vs 59 +/- 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV(1) (r (2) = 0.475; P <.05) and SaO(2) (r (2) = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.

摘要

我们研究了运动期间血浆腺苷（ADO）水平是否发生变化，以及这是否与运动诱发的支气管收缩有关。ADO的基线水平无差异，但运动导致哮喘患者的ADO水平高于健康受试者（86±35 vs 59±16 nmol/L；P<.001）。在哮喘患者中，ADO的升高与第一秒用力呼气容积（FEV₁）降低（r² = 0.475；P<.05）和动脉血氧饱和度（SaO₂）降低（r² = 0.693；P<.05）相关。这些数据表明，腺苷可能参与运动诱发支气管收缩的发生过程。