Myers D M, Varela-Diaz V M
J Clin Microbiol. 1979 Oct;10(4):451-3. doi: 10.1128/jcm.10.4.451-453.1979.
The counterimmunoelectrophoresis (CIE) technique was developed as a diagnostic procedure for ram epididymitis caused by Brucella ovis. CIE test results with sera from naturally and experimentally infected male sheep compared favorably with those obtained by gel diffusion and complement fixation employing the same B. ovis surface R antigen. The main advantage of CIE over gel diffusion consists in a significant reduction of the time required to detect precipitin formation, whereas both methods obviate several of the difficulties encountered with complement fixation tests for B. ovis.
对流免疫电泳（CIE）技术是作为诊断由绵羊布鲁氏菌引起的公羊附睾炎的一种诊断方法而开发的。用来自自然感染和实验感染的雄性绵羊的血清进行CIE试验的结果，与使用相同的绵羊布鲁氏菌表面R抗原通过凝胶扩散和补体结合试验所获得的结果相比，效果良好。CIE相对于凝胶扩散的主要优点在于检测沉淀素形成所需的时间显著减少，而这两种方法都避免了绵羊布鲁氏菌补体结合试验中遇到的一些困难。
