感染与多发性硬化症的病因及发病机制
Infection and the etiology and pathogenesis of multiple sclerosis.
作者信息
Steiner I, Nisipianu P, Wirguin I
机构信息
Department of Neurology, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel.
出版信息
Curr Neurol Neurosci Rep. 2001 May;1(3):271-6. doi: 10.1007/s11910-001-0030-x.
Abstract
Multiple sclerosis (MS) currently defies clinical and scientific definitions, and carries a prognosis that remains practically unchanged despite many years of intensive research. Although the prevailing dogma is that MS is an immune-mediated condition, it fulfills none of the criteria of an autoimmune disease. On the other hand, there is enough significant data to suggest that infectious agents(s) could be involved in either direct damage to the white matter or induce inflammatory responses that secondarily affect the brain. Our goal here is to review the data supporting the possibility that infection has a critical role in the disease, examine the list of potential candidates that have been suggested, and outline an approach regarding the potential role of infectious agents in the etiology and pathogenesis of MS.
摘要
多发性硬化症（MS）目前尚无明确的临床和科学定义，尽管经过多年深入研究，其预后几乎没有变化。虽然普遍观点认为MS是一种免疫介导的疾病，但它并不符合自身免疫性疾病的任何标准。另一方面，有足够多的重要数据表明，感染因子可能直接损害白质或引发炎症反应，进而对大脑产生继发性影响。我们的目标是回顾支持感染在该疾病中起关键作用这一可能性的数据，审视已提出的潜在病原体清单，并概述感染因子在MS病因和发病机制中潜在作用的研究方法。
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