Radaelli Simona T, Platt Simon R
Istituto di Patologia Speciale e Clinica Medico Veterinaria, Facolta di Medicina Veterinaria Milano, Italy.
J Vet Intern Med. 2002 Mar-Apr;16(2):159-63. doi: 10.1892/0891-6640(2002)016<0159:bmidar>2.3.co;2.
The clinical records of 23 dogs (1990-1999) with histopathologically confirmed bacterial meningoencephalomyelitis were evaluated retrospectively. No breed, age, sex, or weight predisposition was found. All the dogs presented with clinical signs of a brain lesion, whereas 5 of 23 had neck pain. Pyrexia was detected in 11 of 23 dogs on admission. CBCs revealed neutrophilic leucocytosis in 7 of 21 dogs and thrombocytopenia in 3 of 21 dogs. The serum chemistry profiles were abnormal in 15 of 21 dogs. The results of cerebrospinal fluid (CSF) analysis were abnormal in 13 of 14 dogs and aerobic CSF culture was positive for bacteria in 1of 8 samples. At postmortem examination, the lesions were localized to the central nervous system. Escherichia coli, Streptococcus, and Klebsiella spp were the most frequently isolated bacteria from cultures collected at postmortem examination. Twelve papers reporting 51 total clinical cases of canine bacterial meningoencephalomyelitis were reviewed. The clinical signs and results of the CBC, serum chemistry, blood culture, and CSF analysis were collated and compared with those of this study. The results of the CSF analysis in this study were similar to those in the literature. CSF cultures documented in the literature were positive for Staphylococcus, Pasteurella. Actinomyces, Nocardia spp, and various anaerobic species including Peptostreptococcus, Eubacterium, and Bacteroides spp.
对23只犬（1990 - 1999年）的临床记录进行了回顾性评估，这些犬经组织病理学确诊患有细菌性脑膜脑脊髓炎。未发现品种、年龄、性别或体重方面的易感性。所有犬均表现出脑部病变的临床症状，而23只中有5只伴有颈部疼痛。23只犬中有11只在入院时检测到发热。21只犬的血常规显示7只中性粒细胞增多，21只中有3只血小板减少。21只犬的血清生化指标异常。14只犬中有13只脑脊液（CSF）分析结果异常，8份样本中有1份脑脊液需氧培养细菌呈阳性。尸检时，病变局限于中枢神经系统。大肠杆菌、链球菌和克雷伯菌属是尸检时培养物中最常分离出的细菌。回顾了12篇报告共51例犬细菌性脑膜脑脊髓炎临床病例的论文。整理了血常规、血清生化、血培养和脑脊液分析的临床症状及结果，并与本研究进行比较。本研究中脑脊液分析结果与文献报道相似。文献中记录的脑脊液培养物对葡萄球菌、巴斯德菌、放线菌、诺卡菌属以及包括消化链球菌、真杆菌和拟杆菌属在内的各种厌氧菌呈阳性。
