Rylander Helena, Djani Dylan M, Cameron Starr
University of Wisconsin-Madison, Madison, WI, United States.
Front Vet Sci. 2022 Apr 5;9:852982. doi: 10.3389/fvets.2022.852982. eCollection 2022.
A 15-month-old male neutered Wirehaired Pointer mixed-breed dog presented with fever and cervical pain. Cerebrospinal fluid (CSF) analysis showed neutrophilic pleocytosis with intracellular bacteria, and culture of CSF grew . The patient became non-ambulatory 3 days after CSF collection. He was treated with low-dose prednisone for 3.5 months and doxycycline for 1 year. Recheck CSF analysis 1 month after diagnosis showed reduction of inflammation and 3 months after diagnosis revealed only increased protein. The patient improved neurologically over several months and was weakly ambulatory 5 months and fully ambulatory 7 months after diagnosis. Whole genome sequencing of the bacterial isolate and a live modified intranasal vaccine similar to the one the dog had been vaccinated with 7 weeks before diagnosis was similar but not an exact match. Bacterial meningitis should be considered, and culture of CSF is recommended, in cases of neutrophilic pleocytosis of CSF.
一只15个月大已绝育的刚毛指示格里芬犬混血雄性犬出现发热和颈部疼痛。脑脊液（CSF）分析显示中性粒细胞增多且存在细胞内细菌，脑脊液培养生长出……。脑脊液采集3天后，该犬无法行走。它接受了3.5个月的低剂量泼尼松治疗和1年的强力霉素治疗。诊断后1个月复查脑脊液分析显示炎症减轻，诊断后3个月仅显示蛋白质增加。该犬在数月内神经功能有所改善，诊断后5个月能勉强行走，7个月后完全恢复行走能力。对分离出的细菌进行全基因组测序，发现一种与该犬在诊断前7周接种的活改良鼻内疫苗相似但不完全匹配的疫苗。脑脊液出现中性粒细胞增多时，应考虑细菌性脑膜炎，并建议进行脑脊液培养。
