Heiberg A
Acta Med Scand. 1975 Oct;198(4):249-61. doi: 10.1111/j.0954-6820.1975.tb19536.x.
The morbidity and mortality in 172 males and 164 females with xanthomatosis have been investigated. Symptoms of coronary heart disease (CHD) were the most frequent initial manifestation of atherosclerotic vascular disease. Angina pectoris was the first symptom in about 3/4 of males as well as females; myocardial infarction was the first event in 26% of the males and 9% of the females. Other manifestations of atherosclerosis were comparatively rare and occurred late in life. Half of the subjects were affected with symptoms of atherosclerotic vascular disease by the age of 52 in men and 62 in women, the mean age for first symptoms being 49 and 56 years, respectively. No significant influence of other CHD risk factors than xanthomatosis and hyperlipidaemia was found in these patients. An increase in the number of cardiovascular deaths was seen in xanthomatosis patients, compared with the general population, in particular in the number of "sudden deaths". Half of the males died before the age of 66 and half of the females before the age of 74.5, which is about 10 and 7 years earlier than predicted at 30 years of age for the normal population. The cumulative relative mortality in both men and women was about twice that expected for the general Norwegian population until 70 years of age.
对172例男性和164例女性黄瘤病患者的发病率和死亡率进行了调查。冠心病（CHD）症状是动脉粥样硬化性血管疾病最常见的初始表现。心绞痛是约3/4男性和女性的首发症状；心肌梗死是26%男性和9%女性的首发事件。动脉粥样硬化的其他表现相对少见且发生在生命后期。一半的男性在52岁、女性在62岁时出现动脉粥样硬化性血管疾病症状，首发症状的平均年龄分别为49岁和56岁。在这些患者中，未发现除黄瘤病和高脂血症之外的其他冠心病危险因素有显著影响。与普通人群相比，黄瘤病患者心血管死亡人数增加，尤其是“猝死”人数。一半男性在66岁前死亡，一半女性在74.5岁前死亡，这比正常人群30岁时预测的死亡年龄早约10年和7年。直到70岁，男性和女性的累积相对死亡率约为挪威普通人群预期死亡率的两倍。
