Way B P, Ball M J, Thorogood M, Cobbe S M, Mann J I
J R Soc Med. 1986 Jul;79(7):391-4. doi: 10.1177/014107688607900705.
A study was performed to determine the morbidity and mortality from ischaemic heart disease (IHD) in patients with heterozygous familial hypercholesterolaemia (FH) and severe hypertriglyceridaemia (pretreatment plasma triglyceride greater than 5 mmol/l). Twenty-nine (38%) of 76 patients with FH and 8(44%) of 18 patients with hypertriglyceridaemia had evidence of IHD. Over a mean follow-up period of 5.5 years, 2 patients with hypertriglyceridaemia died but there were no deaths in patients with FH. This contrasts with earlier reports which showed a high mortality in FH patients. The lower mortality may be due to improved treatment and consequent lower levels of cholesterol.
一项研究旨在确定杂合子家族性高胆固醇血症（FH）和严重高甘油三酯血症（治疗前血浆甘油三酯大于5 mmol/L）患者缺血性心脏病（IHD）的发病率和死亡率。76例FH患者中有29例（38%），18例高甘油三酯血症患者中有8例（44%）有IHD证据。在平均5.5年的随访期内，2例高甘油三酯血症患者死亡，但FH患者无死亡病例。这与早期报告显示FH患者高死亡率形成对比。死亡率较低可能归因于治疗改善及随之降低的胆固醇水平。
