接受治疗的家族性高胆固醇血症患者和严重高甘油三酯血症患者的心血管风险。
Cardiovascular risk in patients with treated familial hypercholesterolaemia and patients with severe hypertriglyceridaemia.
作者信息
Way B P, Ball M J, Thorogood M, Cobbe S M, Mann J I
出版信息
J R Soc Med. 1986 Jul;79(7):391-4. doi: 10.1177/014107688607900705.
A study was performed to determine the morbidity and mortality from ischaemic heart disease (IHD) in patients with heterozygous familial hypercholesterolaemia (FH) and severe hypertriglyceridaemia (pretreatment plasma triglyceride greater than 5 mmol/l). Twenty-nine (38%) of 76 patients with FH and 8(44%) of 18 patients with hypertriglyceridaemia had evidence of IHD. Over a mean follow-up period of 5.5 years, 2 patients with hypertriglyceridaemia died but there were no deaths in patients with FH. This contrasts with earlier reports which showed a high mortality in FH patients. The lower mortality may be due to improved treatment and consequent lower levels of cholesterol.
一项研究旨在确定杂合子家族性高胆固醇血症（FH）和严重高甘油三酯血症（治疗前血浆甘油三酯大于5 mmol/L）患者缺血性心脏病（IHD）的发病率和死亡率。76例FH患者中有29例（38%），18例高甘油三酯血症患者中有8例（44%）有IHD证据。在平均5.5年的随访期内，2例高甘油三酯血症患者死亡，但FH患者无死亡病例。这与早期报告显示FH患者高死亡率形成对比。死亡率较低可能归因于治疗改善及随之降低的胆固醇水平。
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