Fernández M, Keyriläinen J, Serimaa R, Torkkeli M, Karjalainen-Lindsberg M L, Tenhunen M, Thomlinson W, Urban V, Suortti P
Department of Physics, University of Helsinki, Finland.
Phys Med Biol. 2002 Feb 21;47(4):577-92. doi: 10.1088/0031-9155/47/4/303.
Small-angle x-ray scattering (SAXS) patterns are recorded from thin breast tissue samples containing healthy and cancerous regions. The SAXS patterns are compared with histo-pathological observations. The information available from SAXS is reviewed, and a model for scattering from collagen is presented. Scattering patterns of collagen at regions far from the tumours are essentially different from those at tumours. The axial period of collagen fibrils is 65.0 +/- 0.1 nm in healthy regions, and 0.3 nm larger in cancer-invaded regions. The average intensity of scattering from cancerous regions is an order of magnitude higher than the intensity from healthy regions. This is interpreted to arise from an increase of the specific surface area of the scatterers, which is due to a disruption of the molecular and supra-molecular structures in cancerous regions and invasion of new types of cells. The differences of the SAXS patterns are large and distinctive enough to suggest that these phenomena may be utilized in mammography.
从小包含健康和癌性区域的薄乳腺组织样本中记录小角X射线散射（SAXS）图案。将SAXS图案与组织病理学观察结果进行比较。回顾了从SAXS获得的信息，并提出了一种胶原蛋白散射模型。远离肿瘤区域的胶原蛋白散射图案与肿瘤区域的散射图案本质上不同。健康区域中胶原纤维的轴向周期为65.0 +/- 0.1 nm，在癌侵袭区域中长0.3 nm。癌性区域的平均散射强度比健康区域的强度高一个数量级。这被解释为是由于散射体比表面积的增加，这是由于癌性区域中分子和超分子结构的破坏以及新型细胞的侵入所致。SAXS图案的差异足够大且独特，表明这些现象可用于乳腺摄影。
