Dickmeis Thomas, Rastegar Sepand, Lam Chen Sok, Aanstad Pia, Clark Matthew, Fischer Nadine, Rosa Frédéric, Korzh Vladimir, Strähle Uwe
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, F-67404 Illkirch Cedex, C.U. de Strasbourg, France.
Mech Dev. 2002 Apr;113(1):99-102. doi: 10.1016/s0925-4773(02)00006-0.
Proteins of the Extramacrochaetae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm, the cornea, the lens, the brain, the neural crest, the retina and the fins.
