Petrick R J, Kleinmann K
Am J Hosp Pharm. 1975 Oct;32(10):1008-13.
A study of 132 hospitals in New York City was conducted to determine: (1) The usual drug administration and meal serving time schedules used; (2) if oral antibiotics recommended to be given on an empty stomach are actually administered with or near meals; and (3) who is responsible for establishing drug administration time schedules. A structured-disguised questionnaire was used and administered via telephone. Results revealed a wide variation of drug administration time schedules and meal serving times. Meal interference with oral antibiotic absorption was defined as a meal that is served less than one hour before or two hours after an oral antibiotic is scheduled to be administered. The incidence of meal interference ranged from 35 percent to 64 percent. The pharmacy and therapeutics committee, more often than any other group or individual (19.2 percent), was responsible for establishing drug administration times. A formal dosage schedule for orally administered antibiotics is recommended as an effort to reduce the incidence of meal interference with antibiotic absorption. Such a schedule developed at one hospital is presented.
对纽约市132家医院进行了一项研究，以确定：(1) 常用的给药和用餐时间安排；(2) 建议空腹服用的口服抗生素实际是否与餐同服或接近用餐时间服用；(3) 谁负责制定给药时间安排。采用结构化伪装问卷并通过电话进行调查。结果显示给药时间安排和用餐时间差异很大。用餐对口服抗生素吸收的干扰定义为在预定口服抗生素给药前不到一小时或给药后两小时内用餐。用餐干扰的发生率在35%至64%之间。药学与治疗学委员会比其他任何团体或个人（19.2%）更常负责确定给药时间。建议制定口服抗生素的正式给药时间表，以努力降低用餐对抗生素吸收的干扰发生率。本文展示了一家医院制定的此类时间表。
