Vanderveen T W, Robinson L A, Ray M D
Am J Hosp Pharm. 1975 Nov;32(11):1149-53.
Etiologic factors of the Stevens-Johnson syndrome, both drug-related and nondrug-related, are discussed. A description of the Stevens-Johnson syndrome as a symptom complex is presented. Available literature is reviewed and critiqued as to its contribution in helping to define the role of drugs as specific etiologic factors in the syndrome. A patient case history is presented to demonstrate the difficulty of determining the causative agent for the syndrome, and to emphasize the need for a complete drug history before specific agents are implicated. The need for caution and discretion in reporting and implicating agents without the availability of a complete patient history is discussed.
本文讨论了史蒂文斯-约翰逊综合征的病因，包括与药物相关和与非药物相关的因素。文中描述了史蒂文斯-约翰逊综合征作为一种症状复合体的情况。对现有文献进行了综述和批判，以评估其在帮助确定药物作为该综合征特定病因因素方面的作用。文中呈现了一个患者病例史，以说明确定该综合征病原体的困难，并强调在确定特定病原体之前获取完整用药史的必要性。还讨论了在没有完整患者病史的情况下报告和牵连病原体时需要谨慎和审慎的问题。
