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从洛布里·德·布鲁因到酶催化氨通道化：D-氨基葡萄糖-6-磷酸合酶的分子研究

From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase.

作者信息

Teplyakov Alexey, Leriche Caroline, Obmolova Galya, Badet Bernard, Badet-Denisot Marie-Ange

机构信息

Center for Advanced Research in Biotechnology, University of Maryland, Rockville 20850, USA.

出版信息

Nat Prod Rep. 2002 Feb;19(1):60-9. doi: 10.1039/b103713g.

DOI:10.1039/b103713g
PMID:11902440
Abstract

This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.

摘要

本综述总结了关于由氨基葡萄糖-6-磷酸合酶催化合成D-氨基葡萄糖-6-磷酸的知识现状。根据最近的X射线结构，利用大肠杆菌中的该酶分析了L-谷氨酰胺水解、氨转移以及果糖-6-磷酸转化为D-氨基葡萄糖-6-磷酸的机制。本文引用了92篇参考文献，涵盖了截至2001年6月的文献，并强调了哺乳动物氨基葡萄糖-6-磷酸合酶在2型糖尿病中的潜在影响。

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