Baving Lioba, Laucht Manfred, Schmidt Martin H
Central Institute of Mental Health, Germany.
J Child Psychol Psychiatry. 2002 Feb;43(2):265-74. doi: 10.1111/1469-7610.00019.
An atypical EEG pattern of frontal brain activation has been found in infants and adults with emotional disorders. Eighty-two 8-year-old children and 56 11-year-old children were examined with regard to the following questions: 1. Do children who are diagnosed with anxiety disorder exhibit an atypical pattern of frontal brain activation? 2. Can this pattern be demonstrated in children of different ages? and 3. Are there gender differences in these patterns similar to those that have been demonstrated in adults? Baseline EEG activity was subjected to power spectral analysis.
In 8- and 11-year-old anxious girls, the well-known pattern of greater right than left frontal activation emerged that has been found previously in internalizing preschoolers. Healthy girls showed no frontal asymmetry at 8 years of age, and a greater left than right frontal brain activation at 11 years. In contrast, healthy boys demonstrated a significantly greater right than left frontal activation, whereas anxious boys displayed no frontal asymmetry at the age of 8, and a greater left than right frontal activation at the age of 11.
Children suffering from anxiety disorders exhibited a significantly different pattern of frontal brain activation than healthy children without any lifetime diagnosis of mental disorder. Distinct gender differences in frontal activation were found in anxious as well as in healthy children. This could be demonstrated in two samples of different ages.
在患有情绪障碍的婴幼儿和成人中发现了额叶脑激活的非典型脑电图模式。对82名8岁儿童和56名11岁儿童进行了以下问题的检查：1. 被诊断患有焦虑症的儿童是否表现出额叶脑激活的非典型模式？2. 这种模式在不同年龄段的儿童中是否可以得到证实？3. 这些模式中的性别差异是否与在成人中所证实的类似？对基线脑电图活动进行了功率谱分析。
在8岁和11岁的焦虑女孩中，出现了先前在患有内化问题的学龄前儿童中发现的右额叶激活大于左额叶激活的著名模式。健康女孩在8岁时未表现出额叶不对称，在11岁时左额叶脑激活大于右额叶。相比之下，健康男孩表现出右额叶激活明显大于左额叶，而焦虑男孩在8岁时未表现出额叶不对称，在11岁时左额叶激活大于右额叶。
患有焦虑症的儿童表现出的额叶脑激活模式与未被终生诊断为精神障碍的健康儿童明显不同。在焦虑儿童和健康儿童中均发现了额叶激活方面明显的性别差异。这在两个不同年龄段的样本中得到了证实。
