Clarke Adam R, Barry Robert J, McCarthy Rory, Selikowitz Mark
Brain & Behaviour Research Institute, University of Wollongong, Australia.
Psychiatry Res. 2002 Aug 30;111(2-3):181-90. doi: 10.1016/s0165-1781(02)00137-3.
This study investigated EEG differences between two groups of children with attention-deficit/hyperactivity disorder combined type (ADHD), with or without comorbid oppositional defiant disorder (ODD), and normal control subjects. Each group consisted of 20 males. All subjects were between the ages of 8 and 12 years, and groups were matched on age. EEG was recorded during an eyes-closed resting condition from 21 monopolar derivations, which were clustered into nine regions for analysis. The EEGs were Fourier transformed to provide absolute and relative power estimates for the delta, theta, alpha and beta bands. Values were also calculated for the theta/alpha and theta/beta ratios. The ADHD groups had more absolute and relative theta than the control group. Regionally, the ADHD groups had less relative alpha and more relative delta in posterior regions, and less relative beta in the frontal regions, than the control group. These differences were also apparent in both ratio measures. Only two significant topographic differences were found between the ADHD groups, with both of these being less deviant from normality in the ADHD+ODD group than the ADHD group. These results indicate that EEG correlates of ADHD are not clouded by the presence of comorbid ODD, which suggests possible applications in clinical practice.
本研究调查了两组注意缺陷多动障碍合并型（ADHD）儿童（一组伴有对立违抗障碍（ODD），另一组不伴有）与正常对照组儿童之间的脑电图差异。每组由20名男性组成。所有受试者年龄在8至12岁之间，各组年龄匹配。在闭眼静息状态下，从21个单极导联记录脑电图，这些导联被聚类为9个区域进行分析。对脑电图进行傅里叶变换，以提供δ、θ、α和β频段的绝对和相对功率估计值。还计算了θ/α和θ/β比值。ADHD组的绝对和相对θ值均高于对照组。在区域上，与对照组相比，ADHD组后部区域的相对α值较低，相对δ值较高，额叶区域的相对β值较低。这些差异在两种比值测量中也很明显。在ADHD组之间仅发现两个显著的地形差异，且ADHD+ODD组的这两个差异与正常情况的偏离程度均小于ADHD组。这些结果表明，ADHD的脑电图相关性不会因合并ODD而受到影响，这提示了其在临床实践中的可能应用。
