Cine N, Hatemi A C, Erginel-Unaltuna N
Department of Genetics, Institute for Experimental Medical Research, University of Ystanbul, Turkey.
Clin Genet. 2002 Jan;61(1):66-70. doi: 10.1034/j.1399-0004.2002.610113.x.
In this study we examined a possible association between a 27 base pair (bp)-repeat polymorphism in intron 4 of the ecNOS gene and myocardial infarction (MI) in a subgroup of the Turkish population. We compared MI and control groups for the frequencies of the ecNOS alleles and their genotypes. The frequency of the ecNOS 4a/a and 4a/b genotypes was found to be significantly higher in the MI group than in the control group. Interestingly, the frequency of the ecNOS 4a/b polymorphism was found to be significantly higher in the selected MI group (patients with no known secondary risk factors) than in the control and non-selected MI group. We found that the patients with MI had the frequency of the a/a genotype 4.3%, of the a/b genotype 26.6% and the b/b genotype 69.1%. The controls, however, showed only 0.6% for a/a, 18.0% for a/b and 81.4% for the b/b genotype (P < 0.001; chi2 = 13.626). In this study, we show that myocardial infarction is associated with one subtype of ecNOS gene polymorphism.
在本研究中，我们在土耳其人群的一个亚组中检测了内皮型一氧化氮合酶（ecNOS）基因内含子4中27个碱基对（bp）重复多态性与心肌梗死（MI）之间可能存在的关联。我们比较了MI组和对照组中ecNOS等位基因及其基因型的频率。发现MI组中ecNOS 4a/a和4a/b基因型的频率显著高于对照组。有趣的是，在选定的MI组（无已知二级危险因素的患者）中，ecNOS 4a/b多态性的频率显著高于对照组和未选定的MI组。我们发现，MI患者中a/a基因型的频率为4.3%，a/b基因型为26.6%，b/b基因型为69.1%。然而，对照组中a/a基因型仅为0.6%，a/b基因型为18.0%，b/b基因型为81.4%（P<0.001；χ2=13.626）。在本研究中，我们表明心肌梗死与ecNOS基因多态性的一种亚型相关。
