Wan T S K, Yip S F, Yeung Y M, Chan L C, Ma S K
Division of Hematology, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, People's Republic of China.
Ann Hematol. 2002 Mar;81(3):167-9. doi: 10.1007/s00277-001-0423-6. Epub 2002 Feb 16.
We describe a case of acute myeloid leukemia (AML) with abnormal eosinophils in a 44-year-old Chinese woman that was complicated by diffuse alveolar damage (DAD) and pulmonary hemorrhage (PH) shortly after induction chemotherapy. Cytogenetic study of bone marrow cells at diagnosis showed a rare aberration of trisomy X (+X) as the sole acquired karyotypic abnormality. We speculate that tissue damage by cellular constituents of the abnormal eosinophils that were released on cell lysis after chemotherapy might be etiologically linked to the occurrence of fatal pulmonary complications.
我们描述了一名44岁中国女性的急性髓系白血病（AML）病例，该患者伴有异常嗜酸性粒细胞，在诱导化疗后不久并发弥漫性肺泡损伤（DAD）和肺出血（PH）。诊断时对骨髓细胞进行的细胞遗传学研究显示，罕见的X三体（+X）畸变是唯一获得性核型异常。我们推测，化疗后异常嗜酸性粒细胞在细胞裂解时释放的细胞成分造成的组织损伤可能在病因上与致命肺部并发症的发生有关。
