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人参——一种非器官特异性癌症预防剂?

Panax ginseng--a non-organ-specific cancer preventive?

作者信息

Yun T K

机构信息

Laboratory of Experimental Pathology, Korea Cancer Center Hospital, Seoul.

出版信息

Lancet Oncol. 2001 Jan;2(1):49-55. doi: 10.1016/S1470-2045(00)00196-0.

DOI:10.1016/S1470-2045(00)00196-0
PMID:11905620
Abstract

For the past 50 years, the main weapons in the war against cancer have been early detection and surgical removal, radiotherapy, chemotherapy, and attempts to develop gene therapy. However, the results so far are less than ideal. One strategy now is to switch from therapeutic approaches to prevention of cancer by improving lifestyle and by identifying effective natural products as chemopreventive agents. One promising candidate with cancer-preventive effects that are not specific to any organ is Panax ginseng C A Meyer, a herb with a long medicinal history. Its protective influence against cancer has been shown by extensive preclinical and epidemiological studies, but these effects need to be carefully investigated by scientific clinical trials focusing on the major cancer killers stomach, lung, liver, and colorectal cancer.

摘要

在过去的50年里,对抗癌症的主要手段包括早期检测、手术切除、放射疗法、化学疗法以及尝试开发基因疗法。然而,目前的结果并不理想。现在的一种策略是从治疗方法转向通过改善生活方式以及识别有效的天然产物作为化学预防剂来预防癌症。一种具有癌症预防作用且对任何器官都无特异性的有前景的候选物是人参(Panax ginseng C A Meyer),这是一种有着悠久药用历史的草药。广泛的临床前和流行病学研究已表明其对癌症具有保护作用,但这些效果需要通过针对主要癌症杀手——胃癌、肺癌、肝癌和结直肠癌的科学临床试验进行仔细研究。

相似文献

1
Panax ginseng--a non-organ-specific cancer preventive?人参——一种非器官特异性癌症预防剂?
Lancet Oncol. 2001 Jan;2(1):49-55. doi: 10.1016/S1470-2045(00)00196-0.
2
Chemopreventive effect of Panax ginseng.人参的化学预防作用。
Phytother Res. 2009 Oct;23(10):1399-403. doi: 10.1002/ptr.2786.
3
Panax ginseng.人参。
Am Fam Physician. 2003 Oct 15;68(8):1539-42.
4
Epidemiological study on cancer prevention by ginseng: are all kinds of cancers preventable by ginseng?人参防癌的流行病学研究:人参能预防所有类型的癌症吗?
J Korean Med Sci. 2001 Dec;16 Suppl(Suppl):S19-27. doi: 10.3346/jkms.2001.16.S.S19.
5
Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds.人参对非器官特异性癌症预防作用的实验和流行病学证据及活性成分鉴定
Mutat Res. 2003 Feb-Mar;523-524:63-74. doi: 10.1016/s0027-5107(02)00322-6.
6
The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence.人参的防癌潜力:人体及实验证据综述
Cancer Causes Control. 2000 Jul;11(6):565-76. doi: 10.1023/a:1008980200583.
7
Non-organ-specific preventive effect of long-term administration of Korean red ginseng extract on incidence of human cancers.长期服用高丽红参提取物对人类癌症发病率的非器官特异性预防作用。
J Med Food. 2010 Jun;13(3):489-94. doi: 10.1089/jmf.2009.1275.
8
Non-organ specific cancer prevention of ginseng: a prospective study in Korea.人参对非器官特异性癌症的预防作用:韩国的一项前瞻性研究。
Int J Epidemiol. 1998 Jun;27(3):359-64. doi: 10.1093/ije/27.3.359.
9
Panax ginseng exerts antiproliferative effects on rat hepatocarcinogenesis.人参对大鼠肝癌发生具有抗增殖作用。
Nutr Res. 2013 Sep;33(9):753-60. doi: 10.1016/j.nutres.2013.07.005. Epub 2013 Aug 15.
10
Cancer prevention and therapeutics: Panax ginseng.癌症预防与治疗:人参。
Altern Med Rev. 2004 Sep;9(3):259-74.

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Using Pharmacokinetic-Pharmacodynamic Modeling to Study the Main Active Substances of the Anticancer Effect in Mice from -.利用药代动力学-药效学模型研究-对小鼠抗癌作用的主要活性物质。
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Antioxidant and anti-inflammatory properties of ginsenoside Rg1 for hyperglycemia in type 2 diabetes mellitus: systematic reviews and meta-analyses of animal studies.人参皂苷Rg1对2型糖尿病高血糖的抗氧化和抗炎特性:动物研究的系统评价和荟萃分析
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Effects of saffron and its active constituent crocin on cancer management: A narrative review.藏红花及其活性成分藏花素对癌症治疗的影响:一项叙述性综述。
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The Ginsenoside Compound K Suppresses Stem-Cell-like Properties and Colorectal Cancer Metastasis by Targeting Hypoxia-Driven Nur77-Akt Feed-Forward Signaling.人参皂苷Compound K通过靶向缺氧驱动的Nur77-Akt前馈信号抑制干细胞样特性和结直肠癌转移。
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Transcriptome reveals insights into biosynthesis of ginseng polysaccharides.转录组揭示了人参多糖生物合成的见解。
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