Bode A M, Dong Z
Hormel Institute, University of Minnesota, Austin 55912, USA.
Lancet Oncol. 2000 Nov;1:181-8. doi: 10.1016/s1470-2045(00)00029-2.
Chemoprevention can be defined as the use of substances to interfere with the process of cancer development. Although substantial progress has been made in elucidating the basis of carcinogenesis, further advances are needed to identify molecular and cellular targets for effective use of chemopreventive agents. Hundreds of compounds have been identified as potential chemopreventive agents. However, the safety and efficacy of each substance must be thoroughly investigated. Carcinogenesis is a multistage process in which numerous genes are affected. Many of these genes regulate important cellular functions, so they are prime targets for chemopreventive agents. A major focus of our work has been the elucidation of mechanism(s) explaining the anticancer actions attributed to several chemopreventive compounds, especially 'natural compounds' that are considered safe because they are present in commonly consumed foods and beverages. Of particular interest are selected drugs (eg aspirin) and certain dietary factors (eg green and black tea, resveratrol) and their influence on cell-signalling events coinciding with skin cancer promotion. This overview describes recent work from our laboratory and others focusing on molecular mechanisms of selected chemopreventive compounds in growth-related signal transduction pathways and skin cancer.
化学预防可定义为使用物质干扰癌症发展过程。尽管在阐明致癌作用基础方面已取得重大进展，但仍需要进一步推进以确定有效使用化学预防剂的分子和细胞靶点。数百种化合物已被鉴定为潜在的化学预防剂。然而，每种物质的安全性和有效性都必须进行彻底研究。致癌作用是一个多阶段过程，其中许多基因会受到影响。这些基因中的许多调控重要的细胞功能，因此它们是化学预防剂的主要靶点。我们工作的一个主要重点是阐明几种化学预防化合物（尤其是被认为安全的“天然化合物”，因为它们存在于常见的食品和饮料中）抗癌作用的机制。特别令人感兴趣的是某些药物（如阿司匹林）和特定饮食因素（如绿茶和红茶、白藜芦醇）及其对与皮肤癌促进相关的细胞信号事件的影响。本综述描述了我们实验室和其他机构最近的工作，重点关注选定化学预防化合物在生长相关信号转导途径和皮肤癌中的分子机制。
