Aziz Saba W, Aziz Moammir H
Department of Internal Medicine, Division of Endocrinology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Photodermatol Photoimmunol Photomed. 2018 Jan;34(1):35-41. doi: 10.1111/phpp.12336. Epub 2017 Aug 29.
Skin cancer is a major health problem worldwide. It is the most common cancer in the United States and poses a significant healthcare burden. Excessive UVR exposure is the most common cause of skin cancer. Despite various precautionary measures to avoid direct UVR exposure, the incidence of skin cancer and mortality related to it remains high. Furthermore, the current treatment options are expensive and have side effects including toxicity to normal cells. Thus, a safe and effective approach is needed to prevent and treat skin cancer. Chemopreventive strategy using naturally occurring compounds, such as resveratrol, is a promising approach to reduce the incidence of UVR-induced skin cancer and delay its progression. This review highlights the current body of evidence related to chemopreventive role of resveratrol and its molecular mechanisms in UVR-induced skin carcinogenesis.
皮肤癌是全球主要的健康问题。它是美国最常见的癌症，带来了巨大的医疗负担。过度暴露于紫外线辐射（UVR）是皮肤癌最常见的病因。尽管采取了各种预防措施来避免直接暴露于UVR，但皮肤癌的发病率及其相关死亡率仍然很高。此外，目前的治疗方案昂贵且有副作用，包括对正常细胞的毒性。因此，需要一种安全有效的方法来预防和治疗皮肤癌。使用天然存在的化合物（如白藜芦醇）的化学预防策略是一种有前景的方法，可降低UVR诱导的皮肤癌的发病率并延缓其进展。本综述重点介绍了与白藜芦醇的化学预防作用及其在UVR诱导的皮肤癌发生中的分子机制相关的现有证据。
