多糖在真菌中的存在及其可能的作用及其对新技术发展的影响。
Occurrence and possible roles of polysaccharides in fungi and their influence on the development of new technologies.
机构信息
LABEX/FEA (Extraction Laboratory/Faculty of Food Engineering), ITEC (Institute of Technology), UFPA (Federal University of Para), Rua Augusto Corrêa S/N, Guamá, 66075-900 Belém, PA, Brazil.
出版信息
Carbohydr Polym. 2020 Oct 15;246:116613. doi: 10.1016/j.carbpol.2020.116613. Epub 2020 Jun 13.
The article summarizes the roles of polysaccharides in the biology of fungi and their relationship in the development of new technologies. The comparative approach between the evolution of fungi and the chemistry of glycobiology elucidated relevant aspects about the role of polysaccharides in fungi. Also, based on the knowledge of fungal glycobiology, it was possible to address the development of new technologies, such as the production of new anti-tumor drugs, vaccines, biomaterials, and applications in the field of robotics. We conclude that polysaccharides activate pathways of apoptosis, secretion of pro-inflammatory substances, and macrophage, inducing anticancer activity. Also, the activation of the immune system, which opens the way for the production of vaccines. The development of biomaterials and parts for robotics is a promising and little-explored field. Finally, the article is multidisciplinary, with a different and integrated approach to the role of nature in the sustainable development of new technologies.
本文总结了多糖在真菌生物学中的作用及其在新技术发展中的关系。真菌进化与糖生物学化学之间的比较方法阐明了多糖在真菌中的作用的相关方面。此外，基于对真菌糖生物学的了解，有可能开发新技术，例如生产新的抗肿瘤药物、疫苗、生物材料以及在机器人技术领域的应用。我们得出的结论是，多糖可以激活细胞凋亡、促炎物质和巨噬细胞的分泌途径，从而发挥抗癌作用。此外，免疫系统的激活为疫苗的生产开辟了道路。生物材料和机器人部件的开发是一个有前途但尚未得到充分探索的领域。最后，本文是多学科的，对自然在新技术可持续发展中的作用采用了不同的综合方法。
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