Tubbs H
J Trop Med Hyg. 1979 Sep-Oct;82(9-10):191-3.
Forty-five men, with acute gonococcal urethritis, were treated with a single dose regime of Probenecid 1 gm and Procaine penicillin, 4.8 mega-units, yielding a cure in 97 per cent. Multiple antibiotic resistance was noted in 69 per cent of 28 Neisseria gonorrhoeae isolates, and of 19 isolates tested for precise penicillin sensitivity, 58 per cent were resistant to greater than 2 i.u./ml. Serum penicillin levels measured in 3 patients showed adequate duration of plateau levels. The advantages of adopting such a regime are discussed.
45名患有急性淋菌性尿道炎的男性患者接受了丙磺舒1克和普鲁卡因青霉素480万单位的单剂量治疗方案，治愈率达97%。在28株淋病奈瑟菌分离株中，69%检测出多重抗生素耐药，在19株检测青霉素精确敏感性的分离株中，58%对大于2国际单位/毫升的青霉素耐药。对3名患者测量的血清青霉素水平显示平台期水平持续时间足够。文中讨论了采用这种治疗方案的优点。
