McCormick F
University of California San Francisco, Cancer Research Institute, 94115, USA.
Nat Rev Cancer. 2001 Nov;1(2):130-41. doi: 10.1038/35101008.
Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the basis of its molecular characteristics. But although laboratory results have been extremely encouraging, many practical obstacles need to be overcome before gene therapy can fulfil its goals in the clinic. These issues are not trivial, but seem less formidable than the challenge of killing cancers selectively and rationally--a challenge that has been successfully addressed.
通过基因疗法直接靶向癌细胞有潜力基于其分子特征来治疗癌症。尽管实验室结果非常令人鼓舞，但在基因疗法能够在临床上实现其目标之前，还需要克服许多实际障碍。这些问题并非微不足道，但似乎比选择性且合理地杀死癌症这一挑战的难度要小——而这一挑战已经得到成功解决。
