Rekha P S, Kuttan G, Kuttan R
Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
Indian J Exp Biol. 2001 Nov;39(11):1173-5.
Oral administration of brahma rasayana (BR; 50 mg/animal for 10 and 30 days) significantly increased the liver antioxidant enzymes such as superoxide dismutase (SOD), catalase(CAT) and tissue and serum levels of reduced glutathione (GSH). Whole body irradiation suppressed the levels of SOD, CAT and GSH. Reduced activity of SOD, CAT and GSH was significantly elevated by treatment with BR after radiation treatment. Similarly radiation exposure induced increase in serum and liver lipid peroxides was significantly reduced by further treatment with BR. The results indicate that BR could ameliorate the oxidative damage produced in the body by radiation and may be useful as an adjuvant during radiation therapy.
口服婆罗门补养方（BR；每只动物50毫克，持续10天和30天）显著提高了肝脏抗氧化酶的水平，如超氧化物歧化酶（SOD）、过氧化氢酶（CAT）以及组织和血清中还原型谷胱甘肽（GSH）的水平。全身照射会抑制SOD、CAT和GSH的水平。放射治疗后用BR治疗可显著提高SOD、CAT和GSH降低的活性。同样，辐射暴露引起的血清和肝脏脂质过氧化物增加通过进一步用BR治疗而显著降低。结果表明，BR可以改善辐射在体内产生的氧化损伤，并且在放射治疗期间可能作为一种辅助剂有用。
