Zhang Jiangyang, van Zijl Peter C M, Mori Susumu
Department of Radiology, Division of MRI Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Neuroimage. 2002 Apr;15(4):892-901. doi: 10.1006/nimg.2001.1012.
The use of diffusion tensor information as an additional contrast in MR microimaging was investigated in ex vivo mouse brain and isolated hippocampus. Diffusion Tensor Imaging (DTI) provided unique contrast to identify many internal structures of the gray matter such as hippocampus, thalamus, and cortex. In hippocampus, stratum granulosum and stratum pyramidale could be identified using the isotropic water diffusion constant. Stratum moleculare and stratum radiatum were identified from their characteristic fiber architecture revealed by color-coded DTI. Identification of these structures allowed reconstruction of their 3-D volume. Thus, high-resolution DTI has excellent potential as a tool for 3-D characterization of murine brains.
在离体小鼠脑和分离的海马体中研究了将扩散张量信息用作磁共振显微成像中的附加对比剂。扩散张量成像（DTI）提供了独特的对比，以识别灰质的许多内部结构，如海马体、丘脑和皮质。在海马体中，颗粒层和锥体层可通过各向同性水扩散常数来识别。分子层和辐射层则通过彩色编码DTI揭示的特征性纤维结构来识别。这些结构的识别使得它们的三维体积得以重建。因此，高分辨率DTI作为一种用于小鼠脑三维特征描述的工具具有出色的潜力。
