Helin T, Haahtela S, Haahtela T
Division of Allergy, Helsinki University Central Hospital, Helsinki Finland.
Allergy. 2002 Mar;57(3):243-6. doi: 10.1034/j.1398-9995.2002.1s3299.x.
Oral probiotic bacteriotherapy with Lactobacillus rhamnosus has given promising results in small children with food allergy. We studied the effects of similar therapy in teenagers and young adults, who were allergic to birch pollen and apple food and had intermittent symptoms of atopic allergy and/or mild asthma.
We conducted a double-blind, placebo-controlled study, in which respiratory and eye symptoms and use of medications in two groups were compared. Open oral challenge tests with a slice of apple were performed trice: before, during and after the birch-pollen season. There were 18 patients in each group. They used Lactobacillus rhamnosus for 5.5 months; 2.5 months before the pollen season, 1 month during the season (May), and 2 months after.
The results were negative. The treatment did not alleviate the symptoms of the patients or reduce their use of medication during the birch-pollen season or the subsequent 2 months. The treatment did not significantly affect the symptoms caused by apple in the oral challenge tests.
We found no indication of a beneficial treatment effect in our patients. As the number of patients was relatively small, conclusions should be drawn with caution.
口服鼠李糖乳杆菌进行益生菌疗法在患有食物过敏的幼儿中已取得了有前景的结果。我们研究了类似疗法对青少年和年轻人的影响，这些人对桦树花粉和苹果食物过敏，有间歇性特应性过敏症状和/或轻度哮喘。
我们进行了一项双盲、安慰剂对照研究，比较了两组的呼吸道和眼部症状以及药物使用情况。在桦树花粉季节之前、期间和之后分别进行三次用一片苹果进行的开放性口服激发试验。每组有18名患者。他们服用鼠李糖乳杆菌5.5个月；在花粉季节前2.5个月、季节期间（5月）1个月以及之后2个月服用。
结果为阴性。该治疗并未缓解患者的症状，也未减少他们在桦树花粉季节及随后2个月的药物使用。该治疗对口服激发试验中苹果引起的症状没有显著影响。
我们未发现对患者有有益治疗效果的迹象。由于患者数量相对较少，得出结论时应谨慎。
