Francis Martin J O, Lees Rita L, Trujillo Elisa, Martín-Vasallo Pablo, Heersche Johan N M, Mobasheri Ali
Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK.
Int J Biochem Cell Biol. 2002 May;34(5):459-76. doi: 10.1016/s1357-2725(01)00142-x.
Osteoblasts, osteocytes and osteoclasts are specialised cells of bone that play crucial roles in the formation, maintenance and resorption of bone matrix. Bone formation and resorption critically depend on optimal intracellular calcium and phosphate homeostasis and on the expression and activity of plasma membrane transport systems in all three cell types. Osteotropic agents, mechanical stimulation and intracellular pH are important parameters that determine the fate of bone matrix and influence the activity, expression, regulation and cell surface abundance of plasma membrane transport systems. In this paper the role of ATPase pumps is reviewed in the context of their expression in bone cells, their contribution to ion homeostasis and their relation to other transport systems regulating bone turnover.
成骨细胞、骨细胞和破骨细胞是骨的特殊细胞，在骨基质的形成、维持和吸收中发挥着关键作用。骨的形成和吸收严重依赖于细胞内钙和磷酸盐的最佳稳态，以及这三种细胞类型中质膜转运系统的表达和活性。促骨生成因子、机械刺激和细胞内pH值是决定骨基质命运并影响质膜转运系统活性、表达、调节和细胞表面丰度的重要参数。本文在骨细胞中ATP酶泵的表达、它们对离子稳态的贡献以及它们与调节骨转换的其他转运系统的关系的背景下，对其作用进行了综述。
