Oie S H, Fystro D
Appl Microbiol. 1975 Oct;30(4):514-8. doi: 10.1128/am.30.4.514-518.1975.
To evaluate the possibilities of using gamma irradiation for the sterilization of ointments, the effect of irradiation on spores of Bacillus pumilus and Bacillus sphaericus in dry material and in two different kinds of ointments was studied. The results indicate that for sterilization purposes irradiation was less effective in white petrolatum as compared to irradiation in the dry state. No such protective effect was found in a hydrophilic ointment. Accordingly, the sterilization dose needed for the sterilization of an ointment can be decided upon only after inactivation experiments with suitable test organisms in the actual preparation.
为评估使用伽马射线辐照对软膏进行灭菌的可能性，研究了辐照对干燥材料以及两种不同软膏中短小芽孢杆菌和球形芽孢杆菌孢子的影响。结果表明，出于灭菌目的，与在干燥状态下辐照相比，在白凡士林软膏中辐照效果较差。在亲水性软膏中未发现此类保护作用。因此，只有在用实际制剂中的合适试验微生物进行灭活试验后，才能确定软膏灭菌所需的辐照剂量。
