纳加酰胺A，一种从海洋海绵斯氏海绵中提取的具有抗菌活性的缩酚酸肽。
Nagahamide A, an antibacterial depsipeptide from the marine sponge Theonella swinhoei.
作者信息
Okada Yumika, Matsunaga Shigeki, van Soest Rob W M, Fusetani Nobuhiro
机构信息
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Japan.
出版信息
Org Lett. 2002 Sep 5;4(18):3039-42. doi: 10.1021/ol0262791.
[structure: see text] An antibacterial depsipeptide, nagahamide A (1), has been isolated from the marine sponge Theonella swinhoei. Its structure was determined on the basis of spectral and chemical methods. Absolute configuration of amino acid residues was determined by Marfey's analysis, and relative stereochemistry of the polyketide moiety was assigned by comparison of NMR data with those of a model compound.
[结构：见正文] 一种抗菌缩肽，那加酰胺A（1），已从海洋海绵斯氏海绵（Theonella swinhoei）中分离出来。其结构通过光谱和化学方法确定。氨基酸残基的绝对构型通过马尔费方法测定，聚酮部分的相对立体化学通过将核磁共振数据与模型化合物的数据进行比较来确定。
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