Chrysant S G, Lavender A R
Arch Int Pharmacodyn Ther. 1975 Sep;217(1):44-56.
The direct renal hemodynamic effect of two different vasodilators, diazoxide and acetylcholine, in the anesthetized dog, were studied. In 12 dogs (Group 1), diazoxide was given first directly into the renal artery and was followed by the addition of acetylcholine. In 6 dogs (Group 2) the order of drug administration was reversed. The glomerular filtration rate (GFR), the effective renal plasma flow (ERDF), and the excretion of sodium, potassium, chloride, and urine output were determined for both control and experimental (infused) kidneys. Both drugs when given alone resulted in a significant increase of all parameters tested on the experimental kidney, except the ERPF which was spuriously decreased by diazoxide. The addition of either drug upon the first given did not produce and further effect. It was, therefore, concluded that the hemodynamic changes, as well as the handling of electrolytes and water by the kidney, were solely due to the vasodilating properties of both compounds. A local renal tubular effect by diazoxide concerning sodium excretion could not be substantiated by our studies.
研究了两种不同血管扩张剂二氮嗪和乙酰胆碱对麻醉犬的直接肾血流动力学作用。在12只犬（第1组）中，先将二氮嗪直接注入肾动脉，随后加入乙酰胆碱。在6只犬（第2组）中，药物给药顺序相反。测定了对照肾和实验（输注）肾的肾小球滤过率（GFR）、有效肾血浆流量（ERDF）以及钠、钾、氯的排泄量和尿量。两种药物单独使用时，除二氮嗪使ERPF假性降低外，实验肾的所有测试参数均显著增加。在首次给药后添加任何一种药物均未产生进一步影响。因此，得出结论，血流动力学变化以及肾脏对电解质和水的处理完全归因于这两种化合物的血管扩张特性。我们的研究未能证实二氮嗪对钠排泄有局部肾小管作用。
