Olsen U B, Magnussen M P, Eilertsen E
Acta Physiol Scand. 1976 Jul;97(3):369-76. doi: 10.1111/j.1748-1716.1976.tb10276.x.
An increase of the intrarenal pressure to 40 mmHg induced by ureteral constriction or by kidney compression is shown to be followed by increased renal blood flow in anesthetized dogs. This hyperemia is probably the result of enhanced intrarenal prostaglandin activity since it is followed by increased urinary prostaglandin E excretion and is abolished by indomethacin pretreatment. The increase of renal blood flow seems to be due to dilation of the afferent arteriole in order to maintain the filtration pressure. The glomerular filtration rate is thus severely depressed in indomethacin pretreated dogs. Urine and electrolyte excretion is comparably redcued during elevated intrarenal pressure in non-pretreated and in indomethacin pretreated dogs, which suggests that factors other than glomerular filtration rate are involved. Urine osmolarity is positively correlated with renal blood flow, and urine osmolarity increases during elevated intrarenal pressure in non pretreated dogs, whilst urine osmolarity remains unchanged in dogs pretreated with indomethacin.
输尿管结扎或肾脏受压致使肾内压力升至40毫米汞柱时，麻醉犬的肾血流量会增加。这种充血现象可能是肾内前列腺素活性增强的结果，因为随后尿中前列腺素E排泄量增加，且吲哚美辛预处理可消除该现象。肾血流量增加似乎是由于入球小动脉扩张以维持滤过压。因此，在吲哚美辛预处理的犬中，肾小球滤过率严重降低。在未预处理和吲哚美辛预处理的犬中，肾内压力升高期间尿液和电解质排泄量均相应减少，这表明除肾小球滤过率外还涉及其他因素。尿渗透压与肾血流量呈正相关，在未预处理的犬中，肾内压力升高时尿渗透压增加，而在吲哚美辛预处理的犬中尿渗透压保持不变。
