Jensen Sanne, Geymonat Marco, Johnston Leland H
Division of Yeast Genetics, National Institute for Medical Research, London, UK.
Curr Biol. 2002 Mar 19;12(6):R221-3. doi: 10.1016/s0960-9822(02)00756-x.
Activation of Cdc14 phosphatase, controlled by a signalling cascade known as the mitotic exit network, is the final switch that drives cells from mitosis into the next cell cycle. The recent discovery of a novel network that regulates early Cdc14 activation has revealed the unexpected existence of a two-step control of mitotic exit.
由称为有丝分裂退出网络的信号级联所控制的Cdc14磷酸酶的激活,是驱动细胞从有丝分裂进入下一个细胞周期的最终开关。最近发现的一个调节Cdc14早期激活的新网络,揭示了有丝分裂退出存在两步控制这一意外情况。