Folkes Adrian, Brown S David, Canne Lynne E, Chan Jocelyn, Engelhardt Erin, Epshteyn Sergey, Faint Richard, Golec Julian, Hanel Art, Kearney Patrick, Leahy James W, Mac Morrison, Matthews David, Prisbylla Michael P, Sanderson Jason, Simon Reyna J, Tesfai Zerom, Vicker Nigel, Wang Shouming, Webb Robert R, Charlton Peter
Xenova Limited, 957 Buckingham Avenue, Slough, Berks SL1 4NL, UK.
Bioorg Med Chem Lett. 2002 Apr 8;12(7):1063-6. doi: 10.1016/s0960-894x(02)00078-1.
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
我们合成并评估了一系列基于四咪酸和羟基喹啉酮的纤溶酶原激活物抑制剂-1（PAI-1）抑制剂。这些研究鉴定出了几种对PAI-1具有优异活性的化合物。本文描述了这些化合物的设计、合成及构效关系。
