cathelicidin抗菌肽：杀菌活性、作用机制及其在天然免疫中的作用
Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity.
作者信息
Ramanathan Balaji, Davis Elizabeth G, Ross Christopher R, Blecha Frank
机构信息
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5802, USA.
出版信息
Microbes Infect. 2002 Mar;4(3):361-72. doi: 10.1016/s1286-4579(02)01549-6.
Abstract
Antimicrobial peptides are important host-defense molecules of innate immunity. Cathelicidins are a diverse family of potent, rapidly acting and broadly effective antimicrobial peptides, which are produced by a variety of cells. This review examines the classification, antimicrobial spectrum, mechanism of action, and regulation of cathelicidins.
摘要
抗菌肽是天然免疫中重要的宿主防御分子。杀菌肽是一类多样的、强效的、作用迅速且广泛有效的抗菌肽家族，由多种细胞产生。本文综述了杀菌肽的分类、抗菌谱、作用机制及调控。
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