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[静脉注射亚硒酸钠后家兔体内的半数致死量及各器官中的硒浓度]

[LD 50 and selenium concentration in organs following intravenous administration of sodium selenite in the rabbit].

作者信息

Berschneider F, Hannemann O, Hess M, Willer S

出版信息

Arch Exp Veterinarmed. 1975;29(4):615-20.

PMID:1190978
Abstract

In experiments on 72 rabbits, the LD50 of sodium selenite by intravenous injection was found to be 2.24 mg/kg body weight. The clinical picture and pathological changes associated with acute selenium poisoning are described. The increase in selenium concentration was up to nine times the normal in liver and up to six times in kidney and muscle. There was no sign of a return to normal values 24 hours after administration.

摘要

在对72只兔子进行的实验中,发现静脉注射亚硒酸钠的半数致死量为2.24毫克/千克体重。描述了与急性硒中毒相关的临床表现和病理变化。肝脏中硒浓度的增加高达正常水平的九倍,肾脏和肌肉中高达六倍。给药24小时后没有恢复到正常值的迹象。

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Arch Exp Veterinarmed. 1975;29(4):615-20.
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