Knobloch Johannes K-M, Horstkotte Matthias A, Rohde Holger, Kaulfers Paul-Michael, Mack Dietrich
Institut für Medizinische Mikrobiologie und Immunologie, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
J Antimicrob Chemother. 2002 Apr;49(4):683-7. doi: 10.1093/jac/49.4.683.
The pathogenesis of Staphylococcus epidermidis is correlated with biofilm formation. We investigated the effect of three common alcoholic skin disinfectants, ethanol, n-propanol and isopropanol, on the biofilm formation of 37 clinical, icaADBC-positive S. epidermidis isolates. In alcohol-supplemented media 18 strains displayed increased biofilm expression. Sixteen of 19 strains were generally incapable of biofilm formation. In three representative isolates, the increase in biofilm formation was paralleled by increased polysaccharide intercellular adhesin synthesis. Regarding the widespread use of alcoholic skin disinfectants, it is possible that the alcohol-inducible biofilm phenotype of S. epidermidis could add to the development of foreign body-related infections.
表皮葡萄球菌的发病机制与生物膜形成相关。我们研究了三种常见的酒精性皮肤消毒剂，乙醇、正丙醇和异丙醇，对37株临床分离的icaADBC阳性表皮葡萄球菌生物膜形成的影响。在添加酒精的培养基中，18株菌株的生物膜表达增加。19株菌株中有16株通常无法形成生物膜。在三个代表性分离株中，生物膜形成的增加与细胞间多糖黏附素合成的增加平行。鉴于酒精性皮肤消毒剂的广泛使用，表皮葡萄球菌的酒精诱导生物膜表型可能会增加与异物相关感染的发生。
