Lynch H T, Lynch J, Lynch P
Arch Surg. 1975 Oct;110(10):1227-9. doi: 10.1001/archsurg.1975.01360160065010.
Verified breast cancer was present in a father, his mother, and his daughter. His sone had a brain tumor (by history) and his grandson, (ehs sone of the affected daughter), had a histologically verified rhabdomyosarcoma. This familial aggregation of cancers (except for leukemia, which is absent) is consistent with a newly described familial breast cancer syndrome. A single pleiotropic, dominantly transmitted gene, possibly interacting with carcinogenic factors, such as an oncogenic virus, may be the cause. A cancer-control potential exists for tumor associations such as those exhibited in this kindred, as well as for other cancer genetic syndromes where careful consideration is given to all histologic varieties of cancer.
经证实，一位父亲、他的母亲和他的女儿都患有乳腺癌。他的儿子曾患脑瘤（根据病史），而他的孙子（患病女儿的儿子）患有经组织学证实的横纹肌肉瘤。这种癌症的家族聚集现象（白血病除外，家族中无人患白血病）与一种新描述的家族性乳腺癌综合征相符。一个单一的多效性显性遗传基因，可能与致癌因素如致癌病毒相互作用，可能是病因。对于像这个家族所表现出的肿瘤关联以及其他癌症遗传综合征，若能仔细考虑所有癌症的组织学类型，就存在癌症控制的潜力。
