两个患有李-弗劳梅尼癌症家族综合征的家族。
Two families with the Li-Fraumeni cancer family syndrome.
作者信息
Pearson A D, Craft A W, Ratcliffe J M, Birch J M, Morris-Jones P, Roberts D F
出版信息
J Med Genet. 1982 Oct;19(5):362-5. doi: 10.1136/jmg.19.5.362.
Abstract
The first two families to be identified in the United Kingdom with the Li-Fraumeni syndrome of familial cancer are reported. The first family comprises breast carcinoma in the mother and adrenocortical carcinoma, medulloblastoma, and rhabdomyosarcoma in three of her four children, and the second family comprises breast carcinoma in the mother and adrenocortical carcinoma and rhabdomyosacrcoma in two of her three children. All three of the surviving children with malignancy, and one other who has recently died, possess the tissue type antigen B12.
摘要
据报道，在英国首次发现两个患有李-弗劳梅尼家族性癌症综合征的家庭。第一个家庭中，母亲患乳腺癌，她的四个孩子中有三个分别患肾上腺皮质癌、髓母细胞瘤和横纹肌肉瘤；第二个家庭中，母亲患乳腺癌，她的三个孩子中有两个分别患肾上腺皮质癌和横纹肌肉瘤。所有三名患有恶性肿瘤的幸存儿童以及另一名最近去世的儿童都具有组织类型抗原B12。
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