Gunnarsdottir Ingibjorg, Birgisdottir Bryndis E, Benediktsson Rafn, Gudnason Vilmundur, Thorsdottir Inga
Unit for Nutrition Research, Landspitali-University Hospital and Department of Food Science, University of Iceland, Reykjavik, Iceland.
J Hypertens. 2002 Apr;20(4):623-8. doi: 10.1097/00004872-200204000-00018.
To investigate the association between birth size and hypertension within a genetically homogeneous population of high birth weight.
Cohort-study with retrospectively collected data on size at birth.
The study included 4601 men and women born 1914-1935 in Reykjavik, Iceland, who participated in the Reykjavik Study of the Icelandic Heart Association.
Birth size measurements, adult blood pressure (BP) and body mass index (BMI), and family history of hypertension.
Birth weight was inversely related to hypertension in adulthood in women (P for trend < 0.001). The relationship was of borderline significance in men (P for trend = 0.051). A low ponderal index was significantly associated with high BP in women (P for trend = 0.025) but not men (P > 0.05). For women with an adult BMI > 26 kg/m2, the odds ratio for hypertension for those born weighing < 3.45 kg was 2.1 [95% confidence interval, 1.3-3.3, compared with women born weighing > 3.75 kg. The association was only significant in women without a family history of hypertension.
An inverse association between size at birth and adult hypertension was seen in a population of greater birth size than has previously been investigated. The relation was strongest among women born small who were overweight in adulthood, and for those without a family history of hypertension. The results support the hypothesis that the association between birth weight and hypertension is not of genetic origin only. The large birth size of Icelanders might be protective and partly explain the lower mean systolic blood pressure in Iceland than in related nations.
在高出生体重的基因同质人群中研究出生时大小与高血压之间的关联。
采用回顾性收集出生时大小数据的队列研究。
该研究纳入了1914年至1935年出生在冰岛雷克雅未克的4601名男性和女性，他们参与了冰岛心脏协会的雷克雅未克研究。
出生时大小测量值、成人血压（BP）和体重指数（BMI）以及高血压家族史。
成年女性的出生体重与高血压呈负相关（趋势P<0.001）。在男性中，这种关系具有临界显著性（趋势P = 0.051）。低 ponderal 指数与女性的高血压显著相关（趋势P = 0.025），但与男性无关（P>0.05）。对于成年BMI>26kg/m²的女性，出生体重<3.45kg者患高血压的比值比为2.1[95%置信区间，1.3 - 3.3]，而出生体重>3.75kg的女性相比。这种关联仅在无高血压家族史的女性中显著。
在一个出生时大小比之前研究的人群更大的群体中，观察到出生时大小与成人高血压之间存在负相关。这种关系在成年时超重的小出生体重女性中最强，且在无高血压家族史的人群中也是如此。结果支持了出生体重与高血压之间的关联并非仅由遗传因素导致的假说。冰岛人的高出生体重可能具有保护作用，部分解释了冰岛的平均收缩压低于相关国家的原因。
